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1

The Hallmarks of Aging

López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido

Journal:

Year:

2013

Language:

english

File:

PDF, 2.81 MB

english, 2013

2

Progeria: A Paradigm for Translational Medicine

Gordon, Leslie B., Rothman, Frank G., López-Otín, Carlos, Misteli, Tom

Journal:

Year:

2014

Language:

english

File:

PDF, 852 KB

english, 2014

3

Functional Interaction between Acyl-CoA Synthetase 4, Lipooxygenases and Cyclooxygenase-2 in the Aggressive Phenotype of Breast Cancer Cells

Maloberti, Paula M., Duarte, Alejandra B., Orlando, Ulises D., Pasqualini, María E., Solano, Ángela R., López-Otín, Carlos, Podestá, Ernesto J., Santos, Janine

Journal:

Year:

2010

Language:

english

File:

PDF, 1.68 MB

english, 2010

4

Protease degradomics: A new challenge for proteomics

López-Otín, Carlos, Overall, Christopher M.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2002

Language:

english

File:

PDF, 1.65 MB

english, 2002

5

Use of a Multiple-Enzyme/Multiple-Reagent Assay System To Quantify Activity Levels in Samples Containing Mixtures of Matrix Metalloproteinases

Rasmussen, Fred H., Yeung, Nolan, Kiefer, Laura, Murphy, Gillian, Lopez-Otin, Carlos, Vitek, Michael P., Moss, Marcia L.

Journal:

Year:

2004

Language:

english

File:

PDF, 106 KB

english, 2004

6

High-level expression in Escherichia coli of the gene coding for the major structural protein (p72) of African swine fever virus

Freije, JoséM.P., Muñoz, Maribel, Viñuela, Eladio, López-Otín, Carlos

Journal:

Year:

1993

Language:

english

File:

PDF, 469 KB

english, 1993

7

Pharmacogenetics and pharmacogenomics as tools in cancer therapy

Rodríguez-Vicente, Ana E., Lumbreras, Eva, Hernández, Jesus M., Martín, Miguel, Calles, Antonio, Otín, Carlos López, Algarra, Salvador Martín, Páez, David, Taron, Miquel

Journal:

Drug Metabolism and Personalized Therapy

Year:

2016

Language:

english

File:

PDF, 438 KB

english, 2016

8

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Xiaomu Wei, Angela Moncada-Pazos, Santiago Cal, Clara Soria-Valles, Jared Gartner, Udo Rudloff, Jimmy C. Lin, NISC Comparative Sequencing Program, Steven A. Rosenberg, Carlos López-Otín, Yardena Samue

Journal:

Year:

2011

Language:

english

File:

PDF, 874 KB

english, 2011

9

Metabolic Control of Longevity

López-Otín, Carlos, Galluzzi, Lorenzo, Freije, José M.P., Madeo, Frank, Kroemer, Guido

Journal:

Year:

2016

Language:

english

File:

PDF, 2.24 MB

english, 2016

10

Decelerating ageing and biological clocks by autophagy

Lopez-Otín, Carlos, Kroemer, Guido

Journal:

Nature Reviews Molecular Cell Biology

Year:

2019

Language:

english

File:

PDF, 503 KB

english, 2019

11

A fruitful liaison of ZSCAN10 and ROS on the road to rejuvenation

Bárcena, Clea, López-Otín, Carlos

Journal:

Nature Cell Biology

Year:

2017

Language:

english

File:

PDF, 203 KB

english, 2017

12

Withdrawal: Dm1 -MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural development.

Llano, Elena, Pendás, Alberto M., Aza-Blanc, Pedro, Kornberg, Thomas B., López-Otín, Carlos

Journal:

Journal of Biological Chemistry

Year:

2019

Language:

english

File:

PDF, 58 KB

english, 2019

13

Carbotoxicity—Noxious Effects of Carbohydrates

Kroemer, Guido, López-Otín, Carlos, Madeo, Frank, de Cabo, Rafael

Journal:

Year:

2018

Language:

english

File:

PDF, 1.20 MB

english, 2018

14

Molecular mechanisms of normal and pathological aging

López-Otín, Carlos

Journal:

Orphanet Journal of Rare Diseases

Year:

2015

Language:

english

File:

PDF, 260 KB

english, 2015

15

Human Zn-α2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues

José P. Freije, Antonio Fueyo, José Uría, Carlos López-Otin

Journal:

Year:

1991

Language:

english

File:

PDF, 441 KB

english, 1991

16

Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle

Tregei Starr, Robert Child, Tara D. Wehrly, Bryan Hansen, Seungmin Hwang, Carlos López-Otin, Herbert W. Virgin, Jean Celli

Journal:

Cell Host & Microbe

Year:

2012

Language:

english

File:

PDF, 3.12 MB

english, 2012

17

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans

CADIÑANOS, Juan, SCHMIDT, Walter K., FUEYO, Antonio, VARELA, Ignacio, LÓPEZ-OTÍN, Carlos, FREIJE, José M.P.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 432 KB

english, 2003

18

Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray

Kappelhoff, Reinhild, Puente, Xose S., Wilson, Claire H., Seth, Arun, Lopez-Otin, Carlos, Overall, Christopher M.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2017

Language:

english

File:

PDF, 652 KB

english, 2017

19

Location-dependent effects of trauma on oxidative stress in humans

Servia, Luis, Serrano, José C. E., Pamplona, Reinald, Badia, Mariona, Montserrat, Neus, Portero-Otin, Manuel, Trujillano, Javier, Lopez-Delgado, Juan Carlos

Journal:

Year:

2018

Language:

english

File:

PDF, 1.50 MB

english, 2018

20

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

Balbín, Milagros, Fueyo, Antonio, Tester, Angus M, Pendás, Alberto M, Pitiot, Ana S, Astudillo, Aurora, Overall, Christopher M, Shapiro, Steven D, López-Otín, Carlos

Journal:

Nature Genetics

Year:

2003

Language:

english

File:

PDF, 902 KB

english, 2003

21

Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals

Víctor Quesada, Gloria Velasco, Xose S Puente, Wesley C Warren, Carlos López-Otín

Journal:

Year:

2010

Language:

english

File:

PDF, 607 KB

english, 2010

22

β-Turns as structural motifs for the proteolytic processing of seed proteins

Rafael I. Monsalve, Luis Menéndez-Arias, Carlos López-Otin, Rosalía Rodríguez

Journal:

Year:

1990

Language:

english

File:

PDF, 424 KB

english, 1990

23

Determination of polyprotein processing sites by amino terminal sequencing of nonstructural proteins encoded by plum pox potyvirus

Martín, María Teresa, López Otín, Carlos, Laín, Sonia, García, Juan Antonio

Journal:

Year:

1990

Language:

english

File:

PDF, 1.17 MB

english, 1990

24

Breast and Prostate Cancer: An Analysis of Common Epidemiological, Genetic, and Biochemical Features 1

López-Otín, Carlos, Diamandis, Eleftherios P.

Journal:

Endocrine Reviews

Year:

1998

Language:

english

File:

PDF, 445 KB

english, 1998

25

Micromanaging aging with miRNAs

Ugalde, Alejandro P., Español, Yaiza, López-Otín, Carlos

Journal:

Nucleus (Landes Bioscience)

Year:

2011

Language:

english

File:

PDF, 716 KB

english, 2011

26

Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis

Selman, Moisés, López-Otín, Carlos, Pardo, Annie

Journal:

European Respiratory Journal

Year:

2016

Language:

english

File:

PDF, 862 KB

english, 2016

27

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

Otso Lindy, Yrjö T. Konttinen, Timo Sorsa, Yanli Ding, Seppo Santavirta, Arnoldas Ceponis, Carlos López-otín

Journal:

Arthritis & Rheumatism

Year:

1997

Language:

english

File:

PDF, 1.01 MB

english, 1997

28

Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies

Emma Pirilä, Jarkko T Korpi, Timo Korkiamäki, Tiina Jahkola, Ana Gutierrez-Fernandez, Carlos Lopez-Otin, Ulpu Saarialho-Kere, Tuula Salo, Timo Sorsa

Journal:

Wound Repair and Regeneration

Year:

2007

Language:

english

File:

PDF, 3.94 MB

english, 2007

29

Rye Inhibitors of Animal α-amylases Show Different Specifities, Aggregative Properties and IgE-binding Capacities than Their Homologues from Wheat and Barley

Gloria García-Casado, Rosa Sánchez-Monge, Carlos López-Otín, Gabriel Salcedo

Journal:

Year:

1994

Language:

english

File:

PDF, 795 KB

english, 1994

30

Cell autonomous and systemic factors in progeria development

Osorio, Fernando G., Ugalde, Alejandro P., Mariño, Guillermo, Puente, Xose S., Freije, José M.P., López‑Otín, Carlos

Journal:

Biochemical Society Transactions

Year:

2011

Language:

english

File:

PDF, 227 KB

english, 2011

31

Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3

COWELL, Susan, KNÄUPER, Vera, STEWART, Margaret L., D'ORTHO, Marie-Pia, STANTON, Heather, HEMBRY, Rosalind M., LÓPEZ-OTÍN, Carlos, REYNOLDS, John J., MURPHY, Gillian

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 297 KB

english, 1998

32

A Streptomyces glaucescens endodeoxyribonuclease which shows a strong preference for CC dinucleotide

Jesús F. APARICIO, José M. P. FREIJE, Carlos LOPEZ-OTIN, Santiago CAL, Jesús SANCHEZ

Journal:

Year:

1992

Language:

english

File:

PDF, 641 KB

english, 1992

33

Comparative genomic analysis of human and chimpanzee proteases

Xose S. Puente, Ana Gutiérrez-Fernández, Gonzalo R. Ordóñez, LaDeana W. Hillier, Carlos López-Otín

Journal:

Year:

2005

Language:

english

File:

PDF, 372 KB

english, 2005

34

Nuclear Envelope Defects Cause Stem Cell Dysfunction in Premature-Aging Mice

Jesús Espada, Ignacio Varela, Ignacio Flores, Alejandro P. Ugalde, Juan Cadiñanos, Alberto M. Pendás, Colin L. Stewart, Karl Tryggvason, María A. Blasco, José M. P. Freije and Carlos López-Otín

Journal:

The Journal of Cell Biology

Year:

2008

Language:

english

File:

PDF, 1.42 MB

english, 2008

35

Arresten, a Collagen-Derived Angiogenesis Inhibitor, Suppresses Invasion of Squamous Cell Carcinoma

Aikio, Mari, Alahuhta, Ilkka, Nurmenniemi, Sini, Suojanen, Juho, Palovuori, Riitta, Teppo, Susanna, Sorsa, Timo, López-Otín, Carlos, Pihlajaniemi, Taina, Salo, Tuula, Heljasvaara, Ritva, Nyberg, Pia,

Journal:

Year:

2012

Language:

english

File:

PDF, 3.49 MB

english, 2012

36

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] B36. AIRWAY HYPERRESPONSIVENESS - Role Of The Metalloproteinase ADAMTS-12 In The Control Of Allergen-Induced Bronchial Hyperresponsiveness And Inflammation

Paulissen, GeneviÃ¨ve, El Hour, Mehdi, Rocks, Natacha, Gueders, Maud, Bureau, Fabrice, Foidart, Jean-Michel, Lopez-Otin, Carlos, Noel, Agnes, Cataldo, Didier

Year:

2012

File:

PDF, 18 KB

2012

37

Human and mouse proteases: a comparative genomic approach

Puente, Xose S., Sánchez, Luis M., Overall, Christopher M., López-Otín, Carlos

Journal:

Nature Reviews Genetics

Year:

2003

Language:

english

File:

PDF, 2.07 MB

english, 2003

38

Nuclear lamina defects cause ATM-dependent NF- B activation and link accelerated aging to a systemic inflammatory response

Osorio, F. G., Barcena, C., Soria-Valles, C., Ramsay, A. J., de Carlos, F., Cobo, J., Fueyo, A., Freije, J. M. P., Lopez-Otin, C.

Journal:

Genes & Development

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

39

Genetic variants of the trypsin inhibitor from barley endosperm show different inhibitory activities

María A. Moralejo, Gloria García-Casado, Rosa Sánchez-Monge, Carlos Lopez-Otín, Ignacio Romagosa, Jose L. Molina-Cano, Gabriel Salcedo

Journal:

Year:

1993

Language:

english

File:

PDF, 485 KB

english, 1993

40

Tumor Cell Traffic through the Extracellular Matrix Is Controlled by the Membrane-Anchored Collagenase MT1-MMP

Farideh Sabeh, Ichiro Ota, Kenn Holmbeck, Henning Birkedal-Hansen, Paul Soloway, Milagros Balbin, Carlos Lopez-Otin, Steven Shapiro, Masaki Inada, Stephen Krane, Edward Allen, Duane Chung and Stephen

Journal:

The Journal of Cell Biology

Year:

2004

Language:

english

File:

PDF, 4.87 MB

english, 2004

41

Matrix Metalloproteinase-13 Is Highly Expressed in Destructive Periodontal Disease Activity

Hernandez, Marcela, Valenzuela, Maria Antonieta, Lopez-Otin, Carlos, Alvarez, Jesús, Lopez, Jose Manuel, Vernal, Rolando, Gamonal, Jorge

Journal:

Journal of Periodontology

Year:

2006

Language:

english

File:

PDF, 387 KB

english, 2006

42

Protective roles of matrix metalloproteinases: From mouse models to human cancer

López-Otín, Carlos, Palavalli, Lavanya H., Samuels, Yardena

Journal:

Year:

2009

Language:

english

File:

PDF, 263 KB

english, 2009

43

Reprogramming aging through DOT1L inhibition

Soria-Valles, Clara, Osorio, Fernando G., López-Otín, Carlos

Journal:

Year:

2015

File:

PDF, 846 KB

2015

44

Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells

Carrero, Dido, Soria-Valles, Clara, López-Otín, Carlos

Journal:

Disease Models & Mechanisms

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

45

Withdrawal: Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats.

Cal, Santiago, Argüelles, José M., Fernández, Pedro L., López-Otín, Carlos

Journal:

Journal of Biological Chemistry

Year:

2019

File:

PDF, 56 KB

2019

46

Wheat Inhibitors of Heterologous α-Amylases: Characterization of Major Components from the Monomeric Class

Luis Gomez, Rosa Sanchez-Monge, Carlos Lopez-Otin and Gabriel Salcedo

Journal:

PLANT PHYSIOLOGY

Year:

1991

Language:

english

File:

PDF, 1.03 MB

english, 1991

47

Estimation of Copy Number Alterations from Exome Sequencing Data

Valdés-Mas, Rafael, Bea, Silvia, Puente, Diana A., López-Otín, Carlos, Puente, Xose S., Wang, Pei

Journal:

Year:

2012

Language:

english

File:

PDF, 872 KB

english, 2012

48

Matrix metalloproteinases as emerging targets for cancer therapy

José A. Uría, Carlos López-Otín

Journal:

Clinical and Translational Oncology

Year:

2000

File:

PDF, 406 KB

2000

49

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Fernando G. Osorio, Ignacio Varela, Ester Lara, Xose S. Puente, Jesús Espada, Raffaella Santoro, José M. P. Freije, Mario F. Fraga, Carlos López-Otín

Journal:

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

50

Sequence and evolutionary relationships of African swine fever virus thymidine kinase

Rafael Blasco, Carlos López-Ótin, Maribel Muñóz, Ernst-Otto Bockamp, Carmen Simón-Mateo, Eladio Viñuela

Journal:

Year:

1990

Language:

english

File:

PDF, 528 KB

english, 1990

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